Lamivudine Monotherapy as a Holding Strategy in HIV-Infected Children in South Africa
نویسندگان
چکیده
منابع مشابه
Evaluation of Lamivudine Resistance Mutations in HBV/HIV Co-infected Patients
Background and Objective: The drug resistance mutations are key elements in the failure of long-term treatment of Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infections. The mutation in the YMDD motif in the P gene of HBV is the most critical factor in antiviral drug (especially lamivudine) resistance. This study aimed to assess the YMDD motif and other polymerase gene mutati...
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OBJECTIVE To identify baseline demographic and clinical risk factors associated with poor CD4 and weight response after initiation of antiretroviral therapy (ART) in a cohort of human immunodeficiency virus (HIV)-infected children in KwaZulu-Natal, South Africa. METHODS We performed a retrospective cohort study of 674 children initiating antiretroviral therapy at McCord and St. Mary's hospita...
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INTRODUCTION HIV-infected children in resource-poor settings comprise a unique population who require antiretroviral therapy (ART) in careful consideration of social and structural barriers to compliance. Given these aggregate challenges and emerging research into "holding" treatment options, we investigated the efficacy of lamivudine monotherapy (LM) as an alternative to more complex second an...
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In recent years, southern Africa has experienced a substantial and persistent outbreak of measles, with the greatest impact seen in children. As southern Africa is also the region of the globe with the highest prevalence of human immunodeficiency virus (HIV), a large proportion of measles infections in the recent outbreak has been seen in HIV-infected children, including in Botswana, one of the...
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INTRODUCTION Current knowledge on morbidity and mortality in HIV-infected children comes from data collected in specific research programmes, which may offer a different standard of care compared to routine care. We described hospitalization data within a large observational cohort of HIV-infected children in West Africa (IeDEA West Africa collaboration). METHODS We performed a six-month pros...
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ژورنال
عنوان ژورنال: Journal of AIDS & Clinical Research
سال: 2013
ISSN: 2155-6113
DOI: 10.4172/2155-6113.1000246